Synthesis and in vitro cytotoxic activities of some novel steroidal semicarbazones

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: CAKAR, Uros (Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia)
  • Co-author(s): Uros Cakar: Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Marijana Zivkovic: Department of Chemistry, Institute for Chemistry, Technology and Metallurgy, Belgrade, Serbia
    Ivana Matic: Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
    Dusan Sladic: Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
    Natalija Krstic: Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
  • Abstract:

    Background

    Steroids and their derivatives play important roles in human body and can serve as scaffolds for new drugs. Starting with four different steroidal diketones (1a-d), synthesis of eight novel semicarbazones (SCs) (2a-d and 3a-d) was done. 

    Purpose

    This work presents  evaluation of in vitro cytotoxicity of obtained compounds against HeLa

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