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Citrus auraptene induces drug efflux transporter p-glycoprotein expression

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: NABEKURA, Tomohiro (Aichi Gakuin University, School of Pharmacy)
  • Co-author(s): Tomohiro NABEKURA
    Tatsuya KAWASAKI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Kazuyoshi KAWAI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Yu KATO: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    Yuichi UWAI: School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
  • Abstract:

    Background

         P-glycoprotein (MDR1, ABCB1) is a membrane transport protein that is expressed in the intestine, liver, kidney, placenta, and blood-brain barrier.  P-glycoprotein excludes various clinically important drugs, such as verapamil, digoxin, tacrolimus, and vinblastine, from the cells.  Therefore, human P-glycoprotein plays important..

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Last update 4 October 2019

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