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Development of ibuprofen amorphous solid dispersion by hot melt impregnation process using design of experiments approach

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: DDD-027
  • By: SAWICKI, Wiesław (Deparment of Physical Chemistry, Medical University of Gdańsk, Poland)
  • Co-author(s): Prof Wiesław Sawicki, Head Of Department Of Physical Chemistry (Deparment of Physical Chemistry, Medical University of Gdańsk, Gdańsk, Poland)
    Dr Kamil Garbera (Tarchomin Pharmaceutical Works “Polfa” S.A., Warsaw, Poland)
  • Abstract:

    The main aim of the study was to optimize hot melt impregnation (HMI) process of ibuprofen to assure possibly highest amorphisation rate. Amorphisation in most cases should increase dissolution rate and enhance the performance of the drug. Design of experiments (DoE) has been employed to prepare experimental plan. As input variables: ..

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Last update 4 October 2019

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