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Polymer-functionalized Silica-Lipid Hybrid for Improving the Oral Delivery of Poorly Water-Soluble Weak Base Drugs
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-B-107-Tuesday
- By: RAO, Shasha (University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia)
- Co-author(s): Shasha Rao: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
Katharina Richter: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
Tri-Hung Nguyen: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
Ben Boyd: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
Christopher Porter: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
Angel Tan: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
Clive Prestidge: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia - Abstract:
Backgrounds
Silica lipid hybrid (SLH) microparticles are an efficient solid-state lipid-based carrier for the oral delivery of poorly water-soluble compounds.Aims
This study focuses on combining the advantages of SLH with the benefits of Pluronic (Plu) F127 to control lipid digestion and drug release, hence enhancing the oral absorption.Methods
Cinnar
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Last update 28 September 2023