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Simultaneous lc-ms/ms analysis of the plasma concentrations of a cocktail of 5 cytochrome p450 substrate drugs and their metabolites

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: TANAKA, Shimako (University of Shizuoka, Department of Pharmacy Practice & Science, School of Pharmaceutical Sciences, Shizuoka, Japan)
  • Co-author(s): Uchida, Shinya (University of Shizuoka, Shizuoka, Japan)
    Inui, Naoki (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Takeuchi, Kazuhiko (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Watanabe, Hiroshi (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Namiki, Noriyuki (University of Shizuoka, Shizuoka, Japan)
  • Abstract:

    Background: A [quotright]cocktail[quotrightB]approach concurrently detects the activity of multiple cytochrome P450 (CYP) enzymes and involves simultaneous administration of multiple CYP-specific probes followed by the evaluation of their pharmacokinetics in a single experiment.
    Aims: This study aimed to develop a rapid and selective LC-MS/MS..

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Last update 4 October 2019

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