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On-line solid phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS/MS) for quantification of clonazepam in human plasma: an automated method for bioequivalence studies

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: GONCALVES, J.C. (Fac Farmácia-UFRJ, Rio De Janeiro, Brazil)
  • Co-author(s): Neves de Miranda, Claudia (Fac Farmácia-UFRJ, RIO DE JANEIRO, Brazil)
    Germain Noel, François (Dept Farmacologia - ICB/UFRJ, RIO DE JANEIRO, Brazil)
    Caminha, Ricardo (Hospital Universitário - UFRJ, RIO DE JANEIRO, Brazil)
    Da Silva Gram, Karla (Fac Farmácia-UFRJ, RIO DE JANEIRO, Brazil)
  • Abstract:

    A validated method for on-line solid phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry (SPE-HPLC-MS-MS) is described for the quantification of Clonazepam in human plasma. The method involves a dilution of 100 uL of plasma with 50 uL of diazepam (2.5 ng/mL), used as internal standard, vortex-mixing,

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Last update 4 October 2019

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