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Evaluation of mutagenic effects of oestradiol on human leukocytes of Alzheimer Disease, elderly and young donors in the Comet assay

  • At: Amsterdam (the Netherlands) (2012)
  • Type: Poster
  • By: ZIVKOVIC, Lada (Faculty of Pharmacy, Department of Biology and Human Genetics, Belgrade, Serbia)
  • Co-author(s): Spremo-Potparevic, B. (Faculty of Pharmacy, Belgrade, Serbia)
    Djelic, N. (Faculty of Veterinary Medicine, Belgrade, Serbia)
    Stefanovic, S. (Faculty of Pharmacy, Belgrade, Serbia)
    Bajic, V. (Institute of Biomedical Research, Galenika a.d., Belgrade, Serbia)
  • Abstract:

    I.Background: Estrogen has very complex effects on CNS. It protects neurons from noxious effects of ß amiloid
    in vitro

    , ameliorates the cerebral metabolism and increases the level of acetylcholine in the basal forebrain and hippocampus. Its beneficial impact in Alzheimer disease may be attributed in part to its antioxidant activity. On the other


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Last update 4 October 2019

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