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A simple LC-MS/MS method for simultaneous determination of temsirolimus and its major metabolite in human whole blood

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: ZHANG, Xianhua (Peking University Third Hospital, Beijing, China)
  • Co-author(s): Shi, R. (University of California, San Francisco, San Francisco, United States of America)
    Kelley, K. (University of California, San Francisco, San Francisco, United States of America)
    Huang, Y. (University of California, San Francisco, San Francisco, United States of America)
  • Abstract:


    Background:

    Temsirolimus, an ester of sirolimus, is a novel selective inhibitor of the mammalian target of rapamycin (mTOR).
    Aims:

    This study is to develop a simple, fast and specific LC-MS/MS method for the simultaneous determination of temsirolimus and its major metabolite, sirolimus in human whole blood.
    Methods:

    Only 0.1 ml of human blood was

    ..

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Last update 4 October 2019

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