Stability of Rivaroxaban: Kinetic evaluation by alkaline hydrolysis and photodegradation
- At: 2012 FIP Congress in Amsterdam (the Netherlands)
- Type: Poster
- By: WINGERT, Nathalie (Laboratory of Research in Quality Control of Drugs, Porto Alegre, Brazil)
- Co-author(s): Rizzo, T. (Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil)
Steppe, M. (Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil)
Rivaroxaban (RVX) is an oral, direct factor Xa inhibitor approved for prevention of venous thromboembolism. Most of drugs have their stability affected by the conditions they are exposed, such as solvent, pH, temperature, radiation energy, and the presence of catalysts. The stability of RVX was analyzed through alkali medium and UVC radiation.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.