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Direct optical resolution of racemic ritodrine in serum

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: INOTSUME, Nobuo (Hokkaido Pharmaceutical University, Otaru, Japan)
  • Co-author(s): Konda, A. (Hokkaido Pharmaceutical University, Otaru, Japan)
    Soma, M. (Tenshi Hospital, Sapporo, Japan)
    Toda, T. (Hokkaido Pharmaceutical University, Otaru, Japan)
    Hayakawa, T. (Hokkaido Pharmaceutical University, Otaru, Japan)
    Horii, S. (Waters Japan, Tokyo, Japan)
    Kishimoto, S. (Kobe Gakuin University, Kobe, Japan)
    Fukushima, S. (Kobe Gakuin University, Kobe, Japan)
  • Abstract:

    Background and AimsRacemic ritodrine is a tocolytic agent. Although (-)-ritodrine reportedly has a powerful suppressive effect compared with its antipode, clinical information is not available to support this notion. We chirally separated optical isomers of ritodrine in patients’ sera using liquid chromatography (LC) and supercritical fluid


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Last update 4 October 2019

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