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Pharmacological Characterization of Novel Taxus Lignans as Potent Inhibitors for the Initial Stage of Neurodegrative Diseases

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: OHTSUKI, Kenzo (Kitasato University, Molecular Signal Biology, Med. Sci., Sagamihara, Japan)
  • Co-author(s): Okano, T.O. (Kitasato University, Sagamihara, Japan)
  • Abstract:


    I. Background

    Recently, several novel lignans were identified from
    Taxus yunnanensis

    , and demonstrated to exhibit their anti-inflammatory and neuroprotective effects. By the
    in vitro

    assay using three functional brain proteins [MBP, TP (tau protein) and CAMP-2] for GSK-3ß, three
    Taxus

    lignans (A, C and E) were selected as effective mediators for

    ..

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Last update 4 October 2019

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