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The new pH sensitive polycation improves the transfection activity of R8-modified lipid nanoparticles by facilitating siRNA condensation

  • At: Amsterdam (the Netherlands) (2012)
  • Type: Poster
  • By: TORIYABE, Naoyuki (Hokkaido University, Faculty of Pharmaceutical Science, Sapporo, Japan)
  • Co-author(s): Hayashio, Y. (Hokkaido University, Sapporo, Japan)
    Akita, H. (Hokkaido University, Sapporo, Japan)
    Harashima, H. (Hokkaido University, Sapporo, Japan)
  • Abstract:

    ?. Background

    We previously developed octaarginine (R8) and GALA, as a pH-sensitive fusogenic peptide modified a lipid Double-lamellar Multifunctional Envelope-type Nanoparticles Device (R8/GALA-D-MEND) for siRNA delivery. Herein, we report whether a new pH sensitive polycation (pHSP), as a siRNA condensed polycation in response to pH difference,


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Last update 4 October 2019

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