The new pH sensitive polycation improves the transfection activity of R8-modified lipid nanoparticles by facilitating siRNA condensation
- At: 2012 FIP Congress in Amsterdam (the Netherlands)
- Type: Poster
- By: TORIYABE, Naoyuki (Hokkaido University, Faculty of Pharmaceutical Science, Sapporo, Japan)
- Co-author(s): Hayashio, Y. (Hokkaido University, Sapporo, Japan)
Akita, H. (Hokkaido University, Sapporo, Japan)
Harashima, H. (Hokkaido University, Sapporo, Japan)
We previously developed octaarginine (R8) and GALA, as a pH-sensitive fusogenic peptide modified a lipid Double-lamellar Multifunctional Envelope-type Nanoparticles Device (R8/GALA-D-MEND) for siRNA delivery. Herein, we report whether a new pH sensitive polycation (pHSP), as a siRNA condensed polycation in response to pH difference, The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.