Influence of ABCB1 gene plymorphisms on the pharmacokinetics of Rafampin among health Chinese han ethnic subjects

• In: Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: HPS-P-139
• By: QIU, Feng (Sheng jing Hospital of China Medical University, Shenyang, China)
• Co-author(s): Zhao, L.M. (Sheng jing Hospital of China Medical University, Shenyang, China)
  He, X.J. (Sheng jing Hospital of China Medical University, Shenyang, China)
  Sun, Y.X. (Sheng jing Hospital of China Medical University, Shenyang, China)
  
• Abstract:

  Background: Available data suggest the polymorphism in the human ABCB1 gene is associated with intestinal P-glycoprotein expression and pharmacokinetics of the P-glycoprotein substrates.Aims: Rifampin was a known P-glycoprotein substrate, the hypothesis was tested whether this polymorphism also affects the pharmacokinetics of rifampin in Chinese

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