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Influence of GHR and igfbp-3 polymorphisms on RHGH response in Chinese Han patients with idiopathic GH deficiency

  • At: 2011 FIP Congress in Hyderabad (India)
  • Type: Poster
  • By: XU, Xiaowei (Peking Union Medical College Hospital, Bejing, China)
  • Co-author(s): Hou, Wenjing (Peking union medical college hospital, Bejing, China)
    Liu, He (Peking union medical college hospital, Bejing, China)
    Pan, Hui (Peking union medical college hospital, Bejing, China)
    Li, Limin (Peking union medical college hospital, Bejing, China)
    Gong, Fengying (Peking union medical college hospital, Bejing, China)
    Zhu, Huijuan (Peking union medical college hospital, Bejing, China)
    Li, Naishi (Peking union medical college hospital, Bejing, China)
    Zhang, Dianxi (Peking union medical college hospital, Bejing, China)
    Yang, Hongbo (Peking union medical college hospital, Bejing, China)
  • Abstract:

    Background: Recombinant human growth hormone (rhGH) replacement is a standard therapy for children with short stature due to growth hormone deficiency (GHD). rhGH acts through growth hormone receptor(GHR) and IGF-binding protein-3. The study investigated the influences of GHR fl/d3 polymorphism and 4 SNPs in the IGFBP-3 gene (rs2854744, rs3110697, ..

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Last update 4 October 2019

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