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Contribution of secretion transporter to corneal absorption of acebutolol in rabbit eye

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: SASAKI, Hitoshi (Nagasaki University Hospital, Nagasaki, Japan)
  • Co-author(s): Nakashima, Mikiro (Nagasaki University Hospital, NAGASAKI, Japan)
    Ichikawa, Nobuhiro (Nagasaki University Hospital, NAGASAKI, Japan)
    To, Hideto (Nagasaki University Hospital, NAGASAKI, Japan)
    Hamamoto, Tomoyuki (Nagasaki University Hospital, NAGASAKI, Japan)
    Kitahara, Takashi (Nagasaki University Hospital, NAGASAKI, Japan)
    Kawazu, Kouichi (Santen Pharmaceutical Co., Ltd., Nara,, Japan)
  • Abstract:

    In ophthalmic pharmacotherapy, the cornea is considered to be a major pathway for ocular permeation of topically applied drugs. There was a relationship between the permeability of beta-blockers, which are often used in ophthalmic therapy, through an excised rabbit cornea and their lipophilicities. Among them, however, permeability of acebutolol..

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Last update 4 October 2019

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