Enhanced brain targeting by synthesis of a prodrug n-octanoyl lamivudine-5-octanoate and its incorporation in to solid lipid nanoparticles

• In: Industrial Pharmacy - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IPS-P-051
• By: DAHIMA, Rashmi (SOPS,RGTU, Bhopal, India)
• Co-author(s): Chandra Bose, Karthikeyan (SOPS,RGTU, BHOPAL, India)
  Pachori, Ashish (SOPS,RGTU, BHOPAL, India)
  Patil, Pravin (SOPS,RGTU, BHOPAL, India)
  
• Abstract:

  To overcome the limited access of the drug Lamivudine to the brain, N-Octanoyl lamivudine-5-
  
  Octanoate was synthesized and incorporated into solid lipid nanoparticles (Noctanoyllamivudine-
  
  5-octanoate-SLN). N-octanoyllamivudine-5-octanoate was synthesized by
  
  dissolving the lamivudine in pyridine then adding the octanoyl chloride with continuous
  
  ..

The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login