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Enhanced brain targeting by synthesis of a prodrug n-octanoyl lamivudine-5-octanoate and its incorporation in to solid lipid nanoparticles

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: DAHIMA, Rashmi (SOPS,RGTU, Bhopal, India)
  • Co-author(s): Chandra Bose, Karthikeyan (SOPS,RGTU, BHOPAL, India)
    Pachori, Ashish (SOPS,RGTU, BHOPAL, India)
    Patil, Pravin (SOPS,RGTU, BHOPAL, India)
  • Abstract:

    To overcome the limited access of the drug Lamivudine to the brain, N-Octanoyl lamivudine-5-

    Octanoate was synthesized and incorporated into solid lipid nanoparticles (Noctanoyllamivudine-

    5-octanoate-SLN). N-octanoyllamivudine-5-octanoate was synthesized by

    dissolving the lamivudine in pyridine then adding the octanoyl chloride with continuous

    ..

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Last update 4 October 2019

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