Pharmacokinetics and bioequivalence evaluation of cyclobenzaprine tablets

• In: SIG: Bioavailability/Bioequivalence - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: BB-P-019
• By: PORTA, Valentina (College of Pharmaceutical Sciences, University of São Paulo, SÃo Paulo, Brazil)
• Co-author(s): Brioschi, Tatiane Maria de Lima Souza (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Schramm, Simone Grigoleto (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Kano, Eunice Kazue (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Koono, Eunice Emiko Mori (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Ching, Ting Hui (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Serra, Cristina Helena dos Reis (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  
• Abstract:

  Cyclobenzaprine is a centrally acting muscle relaxant similar to tricyclic antidepressants. The purpose of this study was to investigate cyclobenzaprine pharmacokinetics and to evaluate bioequivalence between two different tablets formulations containing the drug. The study was approved by the local Ethical Committee and included 23 healthy..

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