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Enhanced permeation of lovastatin (ls) and pravastatin sodium (ps) across intestinal mucosa by bile salts

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: CHUN, In Koo (Dongduk Women's University, Seoul, South-Korea)
  • Co-author(s): Lee, Kyungmin (Dongduk Women's University, SEOUL, South-Korea)
  • Abstract:

    LS and PS are widely used in the treatment of hypercholesterolemia. However, their bioavailabilities are very low. This study was aimed to increase the permeation rates of both statins, with ultimate goal of enhancing bioavailability. Rabbit intestinal mucosae were mounted over cell-opening of 0.64 cm². Bile salt solutions in saline (3.5 mL) were ..

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Last update 4 October 2019

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