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Delvelopment of flurbifrofen-loaded solid dispersion with surface attached method

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
  • Co-author(s): Oh, Dong Hoon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Jong Suk (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Won Seok (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  • Abstract:

    To improve the solubility and bioavailability of poorly water-soluble flurbiprofen, flurbiprofen-loaded solid dispersion was developed using the spray-drying technique with water, sodium carboxylmethyl cellulose (Na-CMC), and polysorbate 80 (Tween 80). The effect of Na-CMC and Tween 80 on the aqueous solubility and dissolution rate of flurbiprofen ..

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Last update 4 October 2019

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