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Novel ibuprofen-loaded solid dispersion prepared by surface-attached method using poloxamer and hydroxypropyl methylcellulose

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
  • Co-author(s): Kwon, Ram (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Jong Suk (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Oh, Dong Hoon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Kim, Young Ran (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Im, Jong Seub (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  • Abstract:

    To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, ibuprofen-loaded solid dispersion was prepared by surface-attached method with hydroxypropyl methylcellulose (HPMC) and poloxamer. The effect of HPMC and poloxamer on the aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid ..

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Last update 4 October 2019

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