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Improved solubility, dissolution and bioavailability of sibutramine free base via solid dispersions prepared with hpmc2910, poloxamer407 and citric acid

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
  • Co-author(s): Jang, Ki Young (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Won Mo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Jong Suk (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Hong, Myung-Ja (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Lee, Young-Im (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
    Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  • Abstract:

    Solid dispersions prepared with various ratios of poloxamer407, citric acid and HPMC2910 were prepared by surface-attached method and evaluated for improvement of solubility, dissolution and bioavailability of sibutramine free base. The inlet and outlet temperature of spray drying were 110? and 65?, respectively with 5% pump rate and 90 %..

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Last update 4 October 2019

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