Synthesis and antitumor activity of 2-substituted benzimiazoles

• At: 2008 FIP Congress in Basel (Switzerland)
• Type: Poster
• By: Y. ELBAYAA, Rasha (Faculty of Pharmacy, Alexandria, Egypt)
• Co-author(s): M. Youssef, Amal (Faculty of Pharmacy, ALEXANDRIA, Egypt)
  H. Badr, Mona (Faculty of Pharmacy, ALEXANDRIA, Egypt)
  
• Abstract:

  Benzimidazole derivatives are of wide interest because of their diverse biological activity and clinical applications. Pyrrolo[1,2-a]benzimidazoles represent a new class of antitumor agents exhibiting cytotoxic activity against a variety of cancer cell lines. The mechanism of cytotoxicity involves reductive alkylation of DNA accompanied by..

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