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Enhancing effect of aspirin on intestinal absorption of gliadin, wheat allergen, and its mechanism

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: YOKOOJI, Tomoharu (Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Pharmaceutical Services)
  • Co-author(s): Tomoharu Yokooji: Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
    Koh Hamura: School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
    Naoki Ninomiya: School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
    Takanori Taogoshi: Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    Hiroaki Matsuo: Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  • Abstract:

    Background

    Food allergens are absorbed from the intestinal lumen and exhibit their allergenicity. Aspirin exacerbates the food-allergic symptoms by increasing absorption of ingested allergens.

    Methods

    To evaluate the gliadin absorption, plasma concentrations were measured after oral administration by gavage or into a closed intestinal loop in rats.

    ..

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Last update 13 May 2019

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