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Effects of esomeprazole and vonoprazan on the disposition of proguanil.

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: ITO, Kiyomi (Musashino University)
  • Co-author(s): Ryohkan Funakoshi: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan;Pharmacy Administration, Kameda Medical Center, Chiba,
    Yukana Tomoda: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Toshiyuki Kudo: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
    Yoshiaki Yamagishi: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
    Kosho Makino: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
    Hideyo Takahashi: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
    Kenichi Furihata: P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan
    Hiroyuki Kusuhara: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Kiyomi Ito: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
  • Abstract:

    Background

    In vitro inhibitory effect of vonoprazan, a proton pump inhibitor, on CYP2C19 activity is much weaker than that of esomeprazole at their clinically relevant concentrations. However, in a recent clinical study, vonoprazan showed a more potent inhibition compared with esomeprazole against the antiplatelet function of clopidogrel which is..

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Last update 4 October 2019

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