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Impact of cyp genotype and serum il-6 on tramadol pharmacokinetics and drug tolerability

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: TANAKA, Hironari (Hamamatsu University School of Medicine, Hospital Pharmacy)
  • Co-author(s): Hironari Tanaka
    Takafumi Naito: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
    Hikaru Sato: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
    Takanori Hiraide: Clinical Oncology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Yasuhide Yamada: Clinical Oncology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Junichi Kawakami: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
  • Abstract:

    Background

    Clinical responses to oral tramadol show a large variation in cancer patients.

    Methods

    Seventy Japanese cancer patients treated with oral tramadol were enrolled. The predose plasma concentrations of tramadol and its desmethylates were determined at day 4 or later after starting the medication. CYP2D6, CYP2B6, and CYP3A5 genotypes, serum

    ..

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Last update 13 May 2019

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