Impact of cyp genotype and serum il-6 on tramadol pharmacokinetics and drug tolerability

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-HPS-126
• By: TANAKA, Hironari (Hamamatsu University School of Medicine, Hospital Pharmacy)
• Co-author(s): Hironari Tanaka
  Takafumi Naito: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
  Hikaru Sato: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
  Takanori Hiraide: Clinical Oncology, Hamamatsu University School of Medicine, Shizuoka, Japan
  Yasuhide Yamada: Clinical Oncology, Hamamatsu University School of Medicine, Shizuoka, Japan
  Junichi Kawakami: Hospital Pharmacy, Hamamatsu University School of Medicine, Shizuoka, Japan
  
• Abstract:

  Background

  Clinical responses to oral tramadol show a large variation in cancer patients.

  Methods

  Seventy Japanese cancer patients treated with oral tramadol were enrolled. The predose plasma concentrations of tramadol and its desmethylates were determined at day 4 or later after starting the medication. CYP2D6, CYP2B6, and CYP3A5 genotypes, serum
  ..

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