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Delivery of glycoside hydrolases to combat bacterial biofilms

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: THORN, Chelsea (University of South Australia, School of Pharmacy and Medical Science)
  • Co-author(s): Chelsea Renee Thorn: School of Pharmacy and Medical Science and ARC Centre for Excellence in Bio-Nano Science and Technology, University of South Australia, Adelaide, Australia
    Clive A. Prestidge: School of Pharmacy and Medical Science and ARC Centre for Excellence in Bio-Nano Science and Technology, University of South Australia, Adelaide, Australia
    Ben J. Boyd: Drug Delivery Disposition and Dynamics, and ARC Centre for Excellence in Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Melbourne, Australia
    Nicky Thomas: School of Pharmacy and Medical Science and ARC Centre for Excellence in Bio-Nano Science and Technology, University of South Australia, Adelaide, Australia
  • Abstract:

    Background

    The morbidity resulting from chronic wounds is dramatically increasing with 90% of wounds being related to antibiotic-tolerant biofilm infections [1]. Glycoside hydrolases (e.g. alginate lyase), are potent, novel therapies to disrupt biofilms, and increase the susceptibility of residing bacteria to antibiotics [3]. However, the clinical..

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Last update 4 October 2019

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