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Roles of cyp enzymes on formation of fluvastatin metabolites by human liver microsomes

  • At: Basel (Switzerland) (2008)
  • Type: Poster
  • By: TODA, Takaki (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  • Co-author(s): Eliasson, Erik (Karolinska Institutet, Huddinge, Stockholm, Sweden)
    Ask, Birgitta (Karolinska Institutet, Huddinge, Stockholm, Sweden)
    Inotsume, Nobuo (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
    Rane, Anders (Karolinska Institutet, Huddinge, Stockholm, Sweden)
  • Abstract:

    Fluvastatin is a HMG-CoA reductase inhibitor and is metabolized to 5-hydroxy fluvastatin (M-2), 6-hydroxy fluvastatin (M-3) and N-desisopropyl fluvastasin (M-5) in human liver microsomes by CYP enzymes. These metabolites have been considered to be primarily generated by CYP2C9. To elucidate the contribution of CYP enzymes on fluvastatin..

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Last update 4 October 2019

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