Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Roles of cyp enzymes on formation of fluvastatin metabolites by human liver microsomes

  • At: 2008 FIP Congress in Basel (Switzerland)
  • Type: Poster
  • By: TODA, Takaki (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  • Co-author(s): Eliasson, Erik (Karolinska Institutet, Huddinge, Stockholm, Sweden)
    Ask, Birgitta (Karolinska Institutet, Huddinge, Stockholm, Sweden)
    Inotsume, Nobuo (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
    Rane, Anders (Karolinska Institutet, Huddinge, Stockholm, Sweden)
  • Abstract:

    Fluvastatin is a HMG-CoA reductase inhibitor and is metabolized to 5-hydroxy fluvastatin (M-2), 6-hydroxy fluvastatin (M-3) and N-desisopropyl fluvastasin (M-5) in human liver microsomes by CYP enzymes. These metabolites have been considered to be primarily generated by CYP2C9. To elucidate the contribution of CYP enzymes on fluvastatin..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses