Optimization of derivatization procedure for determination of succinic acid

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-ASP-005
• By: JARUKAS, Laurynas (Lithuanian University of Health Sciences, Faculty of Pharmacy, Department of Analytical and Toxicological Chemistry)
• Co-author(s): Laurynas Jarukas
  Justina Kamarauskaitė: Department of Pharmacognosy, Lithuanian University of Health Sciences, Faculty of Pharmacy, Kaunas, Lithuania
  Mindaugas Marksa: Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Faculty of Pharmacy, Kaunas, Lithuania
  Rasa Banienė: Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania
  Sonata Trumbeckaitė: Department of Pharmacognosy, Lithuanian University of Health Sciences, Faculty of Pharmacy, Kaunas, Lithuania
  Liudas Ivanauskas: Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Faculty of Pharmacy, Kaunas, Lithuania
  
• Abstract:

  Background

  It is well known that ischemia/reperfusion injury induces cellular damage, which is accompanied by a variety of metabolic alterations. Several studies indicate that accumulation of mitochondrial metabolite succinate (citric acid cycle intermediate) during ischemia controls reperfusion injury through mitochondrial reactive oxygen..

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