Pharmacokinetics and anti-gastric ulceration activity of oral administration of aceclofenac and esomeprazole in rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: SHIN, Beom Soo (Catholic University of Daegu, College of Pharmacy, Gyeongsan-si, Korea, Republic Of)
  • Co-author(s): Junwoo Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Tae Hwan Kim: Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, United States
    Subindra Kazi Thapa: College of Pharmacy, Wonkwang University, Iksan, Korea, Republic Of
    Hyeon Myeong Jeong: College of Pharmacy, Wonkwang University, Iksan, Korea, Republic Of
    Seung Eun Cheung: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
    Da Young Lee: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
    Youn-Woong Choi: Korea United Pharm. Inc, Seoul, Korea, Republic Of
    Sang-Min Cho: Korea United Pharm. Inc, Seoul, Korea, Republic Of
    Kyu-Yeol Nam: Korea United Pharm. Inc, Seoul, Korea, Republic Of
    Won-Ho Kang: Korea United Pharm. Inc, Seoul, Korea, Republic Of
    Soyoung Shin: College of Pharmacy, Wonkwang University, Iksan, Korea, Republic Of
    Beom Soo Shin: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
  • Abstract:

    Methods

    "EN-US">Aceclofenac alone or in the combination with esomeprazole was orally administered to male Sprague-Dawley rats. Plasma concentrations of aceclofenac, its major metabolite diclofenac, and esomeprazole were simultaneously determined by LC-MS/MS. The gastrointestinal damage was determined by measuring the ulcer area as well as ulcer..

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