Preparation of rivaroxaban nanocrystals with wet ball milling

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: DEMIR, Huriye (Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Technology, ANKARA, Turkey)
  • Co-author(s): Huriye Demir : Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
    Selma Sahin: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
    Levent Oner: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
  • Abstract:

    Background

    The reduced particle size and increased surface area of nanocrystals can lead to increase in the dissolution rate of poorly soluble compounds such as rivaroxaban (RXB).

    Purpose

    The aim of this study was to prepare RXB nanocrystals, and then determine its dissolution rate from these formulations. 

    Methods

    Rivaroxaban as the model compound,

    ..

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