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Agmatine extracts anticonvulsant effect in mice: modulation by alpha-2 adrenoceptors and nitric oxide

  • At: 2004 FIP Congress in New Orleans (USA)
  • Type: Poster
  • By: ROSHANZAMIR, Farshad (Shaheed Beheshti School of Pharmacy, Pharmacology, Tehran, Iran)
  • Co-author(s): Demehri (Tehran School of Medicine, Iran)
    Dehpour (Tehran School of Medicine, Iran)
  • Abstract:

    The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) had a significant and dose-dependent inhibitory effect on pentylenetetrazole (PTZ)-induced seizures. The peak of this anticonvulsant effect was 45 min after agmatine..

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Last update 4 October 2019

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