Modernized traditional Chinese medicine significantly inhibit hepatic enzymes -- address to the risk of herb-drug interactions
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: HU, Oliver Yoa-Pu (National Defense Medical Center, Taipei, China Taiwan)
- Co-author(s): Hsiong, Cheng-Huei (National Defense Medical Center, TAIPEI, China Taiwan)
Pao, Li-Heng (National Defense Medical Center, TAIPEI, China Taiwan)
Hung, Chi-Fung (National Defense Medical Center, TAIPEI, China Taiwan)
Aims: To evaluate the metabolic effects and the potential herb-drug interactions for modernized traditional Chinese medicine (TCM). Methods: A cocktail contained with human liver microsome and was consisted of CYP- and UGT-selective probes: ethoxyresorufin (CYP1A2), dextromethophan (CYP2D6), testosterone (CYP3A4), tolbutamide (CYP2C9) and morphine.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.