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Comparative bioavailability of a drug in a peg based solution using an iprecio® pump infusion and subcutaneous bolus

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: TEIXEIRA, João (Bial - Portela & Cª, S.A., R&D Department, Trofa, Portugal)
  • Co-author(s): João Teixeira: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Nuno Pires: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Bruno Igreja: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Ana Loureiro: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Teófilo Vasconcelos: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Ricardo Lima: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Patrício Soares-da-Silva: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal;MedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal
  • Abstract:

    Background

    iPrecio® microinfusion pumps are programmable, implantable and refillable devices for small animal experimentation, showing advantages over the subcutaneous (SC) bolus administration.

    Purpose

    The aim of this study was to compare the plasma and brain time course pharmacokinetic (PK) profile of a drug delivered from iPrecio pumps versus a SC

    ..

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Last update 4 October 2019

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