Effect of repaglinide on the intestinal permeability of metformin hydrochloride in type 2 diabetic rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: GULSUN, Tugba (Hacettepe University, Faculty of Pharmacy Pharmaceutical Technology Department, ankara, Turkey)
  • Co-author(s): Tugba Gulsun: Faculty of Pharmacy Pharmaceutical Technology Department, Hacettepe University, Ankara, Turkey
    Selma Sahin: Faculty of Pharmacy Pharmaceutical Technology Department, Hacettepe University, ankara, Turkey
  • Abstract:

    Methods

    All animal experiments were conducted using protocols approved by Hacettepe University Animal Experimentations Local Ethics Board. Type 2 diabetes was developed using nicotinamide and streptozotocin. Male Sprague Dawley rats (300–400g; n=6) were used in the in situ single pass intestinal perfusion studies. Permeability of MH across

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