A comprehensive pharmacokinetic modeling of aceclofenac metabolism to major metabolites in healthy volunteers

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: KIM, Eunyoung (Chungang University, Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Seoul, Korea, Republic Of)
  • Co-author(s): Eunyoung Kim: Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
    Wonku Kang: College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
  • Abstract:

    Methods

    Twenty healthy male subjects (mean age 24 years; 20~29 years) took part, and serial plasma samples were obtained following an oral administration (100 mg). Aceclofenac and its three major metabolites were measured by HPLC-MS/MS. Plasma concentrations of aceclofenac and its three metabolites versus time curves were analyzed by a..

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