A comprehensive pharmacokinetic modeling of aceclofenac metabolism to major metabolites in healthy volunteers

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: KIM, Eunyoung (Chungang University, Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Seoul, Korea, Republic Of)
  • Co-author(s): Eunyoung Kim: Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
    Wonku Kang: College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
  • Abstract:

    Background

    Aceclofenac has been used widely as a potent analgesic and anti-inflammatory drug. Aceclofenac is converted to its major  metabolites via CYP2C9-mediated hydroxylation and hydrolysis.

    Purpose

    The main purpose of this study was to develop a pharmacokinetic model reflecting the metabolic pathway of aceclofenac using a compartmental modeling..

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