Transplantation of islet cell clusters as an attractive strategy to overcome hypoxia induced cell death in pancreatic islet transplantation

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: JEONG, Jee-Heon (Yeungnam University, Gyeongsan, Korea, Republic Of)
  • Co-author(s): Jee-Heon Jeong:
    Shiva Pathak: Yeungnam University, Gyeongsan, Korea, Republic Of
    Pham Tung: Yeungnam University, Gyeongsan, Korea, Republic Of
    Chu Soon Yong: Yeungnam University, Gyeongsan, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan, Korea, Republic Of
    Sung Bo Sim: Seoul National University, Seoul, Korea, Republic Of
    Cheol-Hee Ahn: Seoul National University, Seoul, Korea, Republic Of
  • Abstract:

    Methods

    Here, we prepared fully functional islet-cell clusters (ICC) by the hanging drop technique. 

    Results

    In hypoxic environment, the ICC exhibited improved viability and functionality compared to control islets. We transplanted the ICC into subcutaneous space and evaluated their effectiveness in diabetic mice. We report the superiority of the..

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