Effects of fluvastatin on the pharmacokinetics of repaglinide: possible role of cyp3a4 and p-glycoprotein inhibition by fluvastatin

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: BANG, Joon Seok (Sookmyung Women's University, Graduate School of Clinical Pharmacy, Seoul, Korea, Republic Of)
  • Co-author(s): Joon Seok Bang
  • Abstract:

    Methods

    The pharmacokinetic parameters of repaglinide and blood glucose concentrations were also determined in rats after oral  and intravenous administration of repaglinide to rats in the presence and absence of fluvastatin.

    Results

    Compared to the intravenous control, fluvastatin significantly increased the AUC0–∞ of intravenously administered..

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