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Effects of samryungbaekchulsan on the pharmacokinetics of an oral anticancer drug ts-1 in rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: SHIN, Beom Soo (Catholic University of Daegu, College of Pharmacy, Gyeongsan-si, Korea, Republic Of)
  • Co-author(s): Tae Hwan Kim: Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, United States
    Min Gi Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Sungwook Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Seok Won Jeong: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
    Seung Eun Cheung: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
    Da Young Lee: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
    Soyoung Shin: College of Pharmacy, Wonkwang University, Iksan, Korea, Republic Of
    Beom Soo Shin: College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Korea, Republic Of
  • Abstract:

    Background

    TS-1 is an oral fluoropyrimidine anticancer agent that contains tegafur, oteracil, and gimeracil. Tegafur is a prodrug of 5-fluorouracil (5-FU), and gimeracil is an inhibitor of 5-FU metabolism. Although Samryungbaekchulsan (SBS) is a traditional oriental medicine that has been used to treat gastrointestinal disorders, the use of SBS in..

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Last update 4 October 2019

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