Amitriptyline revisited - pharmacogenetic implications in antidepressant treatment

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: MIFSUD BUHAGIAR, Luana (University of Malta, Pharmacy, Lija, Malta)
  • Co-author(s): Luana Mifsud Buhagiar: Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta;, Malta Medicines Authority, San Gwann, Malta
    Godfrey LaFerla: Department of Surgery, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
    Anthony Serracino Inglott: Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta;, Malta Medicines Authority, San Gwann, Malta
    Anton Grech: Department of Psychiatry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
  • Abstract:

    Background

    Tricyclic antidepressants (TCAs) are often overlooked on claims of poor tolerability, although cheaper with a potential efficacy advantage.  Most data available on TCAs derives from an era when genotyping studies were not available. 

    Purpose

    This exploratory research is designed to integrate analytical, clinical and regulatory aspects. 

    ..

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