Targeting cancer metabolism using aldh inhibition with phenformin reverses nsclc

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: KIM, Soo-Youl (National Cancer Center, Division of Cancer Biology, Goyang, Korea, Republic Of)
  • Co-author(s): Soo-Youl Kim: National Cancer Center, Goyang, Korea, Republic Of
    Seon-Hyeong Lee: National Cancer Center, Goyang, Korea, Republic Of
    Joon Kang: National Cancer Center, Goyang, Korea, Republic Of
  • Abstract:

    Background

    US">Cancer cells need alternative energy sources to maintain a steady state of energy. However, the alternative energy source of cancer cell metabolism remains unclear. Non-small-cell lung cancer cells (NSCLC) express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms that have been linked to low overall survival rate. We..

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