Solubilisation of ibuprofen in mixed-surfactant systems containing poloxamer 407 and selected polioxyethylene-derivative surfactants

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: PLUTA, Janusz (Polish Pharmaceutical Society, Department of Drug Form Technology, Warsaw, Poland)
  • Co-author(s): Janusz Pluta: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland;Department of Pharmacology, Opole Medical School (PMWSZ), Opole, Poland
    Kamil P Grela: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
    Dominik M Marciniak: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
    Anna Cap:
    Jakub Burak: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
  • Abstract:

    Background

    The nonionic surfactant poloxamer 407 (P407) is known as a gel-forming excipient, but also as an efficient solubiliser for some lipophilic substances.

    Purpose

    The aim of this study was to measure the influence of chosen polyoxyethylene-derivative surfactants (PEX) on the solubility of ibuprofen (IBU) in thermogelling P407 solutions at..

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