Low-frequency ultrasound facilitated transdermal delivery of asenapine maleate

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: MANIKKATH, Jyothsna (Manipal College of Pharmaceutical Sciences, Pharmaceutics, Manipal, India)
  • Co-author(s): Jyothsna Manikkath: Dept of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, India
    Srinivas Mutalik: Dept of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, India
  • Abstract:

    Background

    Asenapine maleate is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorder. It has very low oral bioavailability due to extensive first pass metabolism. Sublingually administered asenapine maleate has bioavailability of 30%, but causes sublingual adverse reactions.

    Purpose

    The objective of the present study..

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