Atherosclerosis is exacerbated by chitinase-3-like-1 in an amyloid precursor protein transgenic mice

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: SON, Dong Ju (Chungbuk National University, College of Pharmacy, Cheongju, Korea, Republic Of)
  • Co-author(s): Dong Ju Son:
    Young Sik Seo: Department of Molecular Biology and Institute of Nanosensor Biotechnology, Dankook University, Yongin, Korea, Republic Of
    Heonyong Park: Department of Molecular Biology and Institute of Nanosensor Biotechnology, Dankook University, Yongin, Korea, Republic Of
    Dae Youn Hwang: College of Natural Resources & Life Science, Pusan National University, Miryang, Korea, Republic Of
    Sang Bae Han: College of Pharmacy, Chungbuk National University, Cheongju, Korea, Republic Of
    Sanghyeon Kim: Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, United States
    Jin Tae Hong: College of Pharmacy, Chungbuk National University, Cheongju, Korea, Republic Of
  • Abstract:

    Background

    Although the critical role of amyloid precursor protein (APP) on vascular diseases associated with Alzheimer’s disease (AD) has been demonstrated, the underlying molecular mechanisms and physiological consequences are unclear. 

    Purpose

    We aimed to evaluate vascular inflammation and atherosclerosis in Swedish mutant of human APP transgenic..

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