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Development of solid systems using hot melt extrusion to improve itraconanazole dissolution

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MALAQUIAS, Lorena (University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC), Brasilia, Brazil)
  • Co-author(s): Lorena Malaquias: Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia, Brazil
    Heidi Schulte: Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia, Brazil
    Taís Gratieri: Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia, Brazil
    Guilherme Gelfuso: Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia, Brazil
    Marcílio Cunha-Filho: Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia, Brasilia, Brazil
  • Abstract:

    Backgrounds

    Hot melt extrusion (HME) is an advantageous technique to produce drug delivery systems using continuous and solvent free process. One of its advantages is in obtaining solid solutions improving the solubility of drugs in water.

    Aims

    This work aim to develop HME systems of itraconazole (ITZ) to improve its solubility, combining three

    ..

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Last update 4 October 2019

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