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Pyxinol ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: WANG, Hongbo (Yantai, China)
  • Co-author(s): Jinbo Ma: Key lab of Molecular Pharmacology and drug evaluation , Yantai University, Yantai, China
    Yanting Yang: Key lab of Molecular Pharmacology and drug evaluation, Yantai University, Yantai, China
    Hongbo Wang: Key Lab of Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai, China
    Fenghua Fu: Key lab of Molecular Pharmacology and drug evaluation, Yantai University, Yantai, China
  • Abstract:

    Backgrounds

    Cisplatin is a chemotherapeutic agent against solid tumors, however, the cisplatin time- and dose-dependent nephrotoxicity is the main adverse effect of cisplatin. 

    Aims

    In this study, we investigated whether the pyxinol (DQ) had protective effects against cisplatin-induced nephrotoxicity. 

    Methods

    To clarify it, one in vivo model of

    ..

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Last update 4 October 2019

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