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Effects of CES1 genetic variants on its gene expression, and clopidogrel pharmacokinetics and pharmacodynamics

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NEUVONEN, Mikko (University of Helsinki, Clinical Pharmacology, Helsinki, Finland)
  • Co-author(s): Mikko Neuvonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Katriina Tarkiainen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Aleksi Tornio: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Päivi Hirvensalo: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Tuija Tapaninen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Maria Paile-Hyvärinen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Matti Itkonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Mikko Holmberg: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Vesa Kärjä: Department of Pathology, Kuopio University Hospital, Kuopio, Finland
    Ville Männistö: Department of Medicine, University of Eastern Finland, Kuopio, Finland
    Pertti Neuvonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Jussi Pihlajamäki: Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland
    Janne Backman: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Mikko Niemi: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • Abstract:

    Backgrounds

    Although carboxylesterase 1 (CES1) has a recognized role in drug metabolism and its activity shows marked interindividual variability, few studies have investigated the effects of genetic variants on CES1 expression in humans.

    Aims

    Our aim was to investigate effects of genetic variants on CES1 gene expression, and clopidogrel

    ..

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Last update 4 October 2019

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