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Identification of aryl substituted pyrimidine derivatives dual targeting erα and VEGFR-2 as anti-breast cancer agents

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: XIANG, Hua (China Pharmaceutical University, Medicinal Chemistry, Nanjing, China)
  • Co-author(s): Hua Xiang: Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
    Zhichao Tang: Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
    Guoshun Luo: Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
    Kejing Lao: Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
  • Abstract:

    Backgrounds

    Recently, a reported experimental treatment of estrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate inspired us to assume that a multiple ligand of ER and Vascular Endothelial Growth Factor Receptor (VEGFR) may exhibit enhanced activity against breast cancer with fewer disadvantages. 

    Aims

    Pyrimidine,

    ..

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Last update 4 October 2019

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