Effect of time of administration on the pharmacokinetics of chlorpropamide in healthy human volunteers.

• In: SIG Bioavailability/Bioequivalence Posters
• At: New Orleans (USA) (2004)
• Type: Poster
• Poster code: BB-P008
• By: KOLAWOLE, Jacob (University of Jos, Dept of Pharmaceutical Chemistry, Jos, Nigeria)
• Co-author(s): Thaddeus (Department of Pharmaceutical Chemist, Nigeria)
  
• Abstract:

  Circadian changes of the acrophases of endogenous substances, hormones (e.g. insulin) and enzymes (e.g. phase I & II metabolic enzymes) have been shown to affect drug pharmacokinetic profile. Chlorpropamide controls the plasma glucose level by inducing or enhancing insulin secretion in diabetes type II. This study was designed to investigate the..

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