Mitochondrial permeability transition induced by tetrandrine could be attributed to reactive oxygen species: from cytochrome p450
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: QI, Xinming (Shanghai Institute of Materia Medica, Shanghai, China)
- Co-author(s): Zhang, yunhai (Shanghai Institute of Materia Medica, SHANGHAI, China)
Liu, linlin (Shanghai Institute of Materia Medica, SHANGHAI, China)
Xiao, ying (Shanghai Institute of Materia Medica, SHANGHAI, China)
Tetrandrine possesses a potential hepatotoxicity, while its mechanisms remain to be elucidated. Here we reported that reactive oxygen species (ROS) from cytochrome P450 (CYP450) plays an important role in mitochondrial permeability transition (MPT) induced by tetrandrine. Using primary rat hepatocytes as a model, we found that vitamine C and other .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.