Study on the conversion of novel drug potassium 2-(1-hydroxypentyl)-benzoate (dl-phpb), a pro-drug of 3-n-butylphthalide (dl-nbp)
- At: 2007 FIP Congress in Beijing (China)
- Type: Poster
- By: JIANG, Li (Institute of Meteria Medica, Beijing, China)
- Co-author(s): XU, shaofeng (Institute of Meteria Medica, BEIJING, China)
Wang, ling (Institute of Meteria Medica, BEIJING, China)
Wang, xiaoliang (Institute of Meteria Medica, BEIJING, China)
Dl-NBP is a novel agent for treatment of brain ischemia. PHPB, a potential prodrug of dl-NBP, was designed to increase water solubility of dl-NBP, which can be administrated intravenously and orally. The conversion of PHPB to dl-NBP was investigated in vitro and in vivo. To determine the level of PHPB and active drug dl-NBP, the HPLC method was.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.